Expressions are made throughout life, causing lines like smile lines to form with time. If you are interested in smoothing our smile lines for a more youthful appearance, Restylane Defyne or Refyne may be able to help.

What Are Restylane Defyne and Refyne?

Restylane Refyne and Defyne are injectable dermal fillers made to treat mild to severe smile lines. Restylane Refyne is created to address mild to moderate lines, while Restylane Defyne is created to treat moderate to severe lines.  Both are created with hyaluronic acid to smooth nasolabial folds, which extend from the nose to the sides of the mouth.

What to Expect During Treatment

Restylane Refyne and Defyne treatments are performed in-office on an outpatient basis. A topical numbing cream will be applied to the treatment area to ensure your comfort. Then, a fine, thin needle will be used to inject Restylane Refyne or Defyne into the treatment area. Treatment should take no longer than one hour to complete.


There is no downtime associated with Restylane Refyne and Defyne treatments. Mild swelling and redness near the injection site is normal and should resolve within a week. A follow-up appointment may be needed after about two weeks to check results. While one treatment may be sufficient, some patients may require more than one to see optimal results. Results are long lasting and can last up to 12 months.

If you are interested in treating your smile lines with Restylane Refyne or Defyne, contact our Ft. Myers office today to schedule your initial consultation.

Frequently Asked Questions

Can you use Restylane Defyne in lips?

Restylane Defyne can be used to add subtle volume and a more natural shape to the lips. Its also an effective option for nasolabial folds and other signs of aging in the lower and mid face.

How long does Restylane Defyne last in lips?

Restylane Defyne typically lasts around 12 months but areas such as the lips can metabolize fillers faster because of their constant movements. Dr. Golosow can give you the best idea of how long your fillers will last.

Does Restylane Refyne work immediately?

Like other fillers, Refyne can produce instantly noticeable results. However, it can take 1-2 weeks for swelling to subside and for your final results to emerge.

How long does Restylane Refyne last?

Restylane Refyne can last around 12 months, although this can be dependant on a variety of factors. Dr. Golosow can give you the best estimate of how long you can expect your results to last.